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Tear retention enhancement via in-situ gel formation by hydroxypropyl guar cross-linking with borate ions (HP-Guar Borate Gel)

Target: HP-Guar Borate Gel
Molecular classification: Polysaccharide, Hydrogel, Polymer network

Overview

This target refers to the mechanism of tear retention enhancement achieved through the in-situ gel formation of hydroxypropyl guar (HP-guar) cross-linked with borate ions. Upon instillation, HP-guar interacts with borate ions present in the formulation and tear film, forming a viscoelastic hydrogel matrix. This matrix prolongs the retention of lubricants and demulcents on the ocular surface, mimicking the natural mucin layer and providing sustained hydration and protection for epithelial cells in dry eye conditions.

Other names: Hydroxypropyl Guar Borate Crosslinked GelIn-situ Gel Forming Artificial TearsHP-Guar Artificial TearsSystane

Mechanism of action

In-situ gel formation on the ocular surface to enhance tear retention and lubrication.

Biological functions

Tear film stabilizationOcular surface lubricationWater retentionMucomimetic action

Disease associations

Dry eye disease

Safety considerations

Hypersensitivity to componentsPotential for blurred vision upon instillation

Interacting drugs

Artificial tears (Systane)

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