Target intelligence / Profile preview

Teashirt zinc finger homeobox 1 (TSHZ1)

Target: TSHZ1
Molecular classification: Transcription factor, Zinc finger protein, Homeobox protein

Overview

Teashirt zinc finger homeobox 1 (TSHZ1) is a C2H2-type zinc finger and homeobox domain-containing transcription factor, key for embryonic development, particularly of craniofacial structures, the middle ear, soft palate, skeletal system, and specific neurons. TSHZ1 is required for survival and functional organization of certain motor neurons (notably phrenic and hypoglossal) and olfactory bulb interneurons. Mutations in this gene are linked to congenital aural atresia and olfactory deficits in humans, and loss of TSHZ1 in mice causes perinatal lethality with severe morphological and neurodevelopmental abnormalities. TSHZ1 is also recognized as a serologically defined colon cancer antigen, though currently there are no clinically approved drugs targeting this gene[1][2][3][4][6][7].

Other names: Teashirt homolog 1TSHZ1SDCCAG33TSH1NY-CO-33Antigen NY-CO-33Serologically defined colon cancer antigen 33CAAteashirt homolog 1antigen NY-CO-33

Biological functions

Transcriptional regulationEmbryonic developmentCraniofacial and skeletal developmentNeuronal development (including olfactory bulb and motor neuron differentiation)

Disease associations

Congenital aural atresia (craniofacial developmental disorder)Olfactory dysfunction (including phenotypes like hyposmia)Potential cancer biomarker (serologically defined colon cancer antigen 33)

Safety considerations

Mutations associated with developmental disorders (no direct safety/therapeutic concern as no drugs are listed)

Biomarkers

TSHZ1 (as a marker for congenital aural atresia and potentially for certain cancers)

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