Tectorin beta (TECTB)

Tectorin beta (TECTB) is a non-collagenous glycoprotein, primarily identified as a structural constituent of the tectorial membrane in the cochlea of the inner ear[1][3][4]. It belongs to the zona pellucida domain-containing protein family, forming part of the matrix that interacts mechanically with hair cell bundles to enable sound wave transduction into neural signals[4][5]. Tectorin beta helps modulate the biomechanics of the tectorial membrane, specifically affecting its radial displacement and cochlear sensitivity[3]. Mutations in the TECTB gene can cause disruptions in cochlear tuning and are implicated in hereditary sensorineural hearing loss and auditory pathologies such as HDR syndrome[3][4]. In model organisms, TECTB plays upstream roles in otolith development and macular structural integrity[5]. No direct therapeutic drugs or mechanisms of action targeting Tectorin beta are reported, and it is not considered a pharmacological receptor, enzyme, transporter, or other classical therapeutic target.

Other names

Beta-tectorinTECTBβ-tectorin