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Target intelligence / Profile preview
TEK receptor tyrosine kinase (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor tyrosine kinase
01
Overview
TEK receptor tyrosine kinase (TIE2) is a cell surface receptor expressed primarily in endothelial cells and hematopoietic stem cells. It plays a critical role in vascular development, angiogenesis, and communication between endothelial cells and smooth muscle cells. Activation by angiopoietins, particularly Ang1, initiates signaling pathways that regulate endothelial cell survival, proliferation, and vessel integrity. Mutations leading to constitutive activation of TIE2 are associated with venous malformations, and TIE2 is also implicated in tumor angiogenesis.
- Other names
- Angiopoietin-1 receptorCD202B
02
Mechanism of action
Tyrosine kinase inhibition/activation modulation
03
Biological functions
Vascular developmentAngiogenesisHematopoiesisCell survivalCell proliferationCell differentiationSignal transduction
04
Disease associations
Venous malformationsTumor angiogenesis
05
Safety considerations
Potential for disrupting normal vascular development and homeostasisOff-target effects on other tyrosine kinases
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