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Target intelligence / Profile preview
TEK Tyrosine Kinase Receptor (Tie2)
- Target
- Tie2
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
Tie2 (TEK Tyrosine Kinase Receptor) is a receptor tyrosine kinase primarily expressed on endothelial cells, playing a critical role in angiogenesis, vascular stability, and remodeling. It is activated by Angiopoietin-1 (Ang1), leading to downstream signaling through pathways such as PI3K-Akt and MAPK/ERK, promoting endothelial cell survival, proliferation, and migration. Angiopoietin-2 (Ang2) acts as a context-dependent antagonist or partial agonist. Tie2 is a key therapeutic target in cancer, with antiangiogenic therapies aimed at inhibiting its activity to suppress tumor growth. Mutations in TEK are associated with venous malformations.
- Other names
- CD202BAngiopoietin-1 receptor
02
Mechanism of action
Inhibition of Tie2 signaling, preventing angiogenesis and tumor growth; modulation of immune cell activity within the tumor microenvironment
03
Biological functions
AngiogenesisVascular developmentVascular remodelingVascular stabilitySignal transductionAnti-inflammatory barrier functionHematopoiesis
04
Disease associations
Venous malformationsCancer angiogenesis
05
Safety considerations
Potential for off-target effects on normal angiogenesisRisk of vascular instabilityImmune-related adverse events
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