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Tektin-2 (TEKT2)

Target: TEKT2
Molecular classification: Cytoskeletal protein, Filament-forming protein, Structural protein (flagellar/ciliary component)

Overview

Tektin-2 is a filament-forming cytoskeletal protein of the tektin family, essential for the assembly and structural integrity of flagellar and ciliary microtubules. It is specifically expressed in the testis, localizes to the flagella of mature sperm, and is indispensable for proper sperm motility, fertilization, and mitochondrial function. Mutations in Tektin-2 have been associated with defective sperm flagella and reduced motility, contributing to male infertility. Additionally, upregulation of Tektin-2 has been observed in podocytes in diabetic nephropathy, where it may participate in abnormal cytoskeletal remodeling

Other names: Tektin-2TEKT2TEKTIN-TTEKTB1Tektin-B1Testicular tektinTesticular tektin B1-like proteinh-tektin-ttektin 2 (testicular)tektin-B1tektin-t

Biological functions

Sperm flagellum structure and assemblyMaintenance of axonemal integrity (the core component of sperm and cilia flagella)Mitochondrial function in spermatozoaCytoskeletal organization

Disease associations

Sperm motility disorders (male infertility, especially asthenozoospermia)Possible involvement in diabetic nephropathy (cytoskeletal remodeling in podocytes)

Biomarkers

Sperm motility and male fertility (Tektin-2 levels are linked to sperm motility, fertilization rates, and overall assisted reproduction outcomes)

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