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Tektin-4 (TEKT4)

Target: TEKT4
Molecular classification: Filament-forming cytoskeletal protein, Tektin family, Structural protein

Overview

Tektin-4 is a structural, filament-forming protein that associates with tubulin in microtubules, primarily functioning in sperm flagella to stabilize the axoneme and regulate motility. Sequence analyses show it contains a conserved tektin domain and coiled-coil regions typical of filamentous cytoskeletal proteins[1]. TEKT4 genetic variations have been linked to altered microtubule dynamics and increased resistance to paclitaxel in breast cancer, as well as to impaired sperm function and male infertility[3][1]. TEKT4 is not a conventional therapeutic target, but its genetic variants are of interest as cancer resistance biomarkers.

Other names: Tektin-4TEKT4MGC27019epididymis secretory sperm binding proteintektin-4

Mechanism of action

Not drug-targeted; however, variants in TEKT4 deregulate microtubule stability and antagonize paclitaxel-induced microtubule stabilization

Biological functions

Sperm flagellar structure and motilityMicrotubule stabilization

Disease associations

Cancer (specifically associated with breast cancer resistance to paclitaxel)Male infertility (through defects in sperm motility)

Interacting drugs

None directly acting; however, variations in TEKT4 affect response to paclitaxel

Biomarkers

TEKT4 germline variations as predictive markers for resistance to paclitaxel in breast cancer

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