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Target intelligence / Profile preview
Tektin bundle-interacting protein 1 (TEKTIP1)
- Target
- TEKTIP1
- Molecular classification
- Microtubule inner protein (MIP), Axonemal protein, Other (not a receptor, enzyme, transcription factor, ion channel, transporter, or histone modifier)
01
Overview
Tektin bundle-interacting protein 1 (TEKTIP1) is a microtubule inner protein highly expressed in the testis, especially in early and late spermatids, and specifically localized along the sperm flagella[1][3]. TEKTIP1 interacts strongly with tektin 3, supporting the structural integrity and organization of tektin bundles within axonemal doublet microtubules[1]. Knockout mice lacking TEKTIP1 exhibit moderately disorganized sperm axonemal structures and reduced sperm motility, resulting in male subfertility[1]. TEKTIP1 is not a canonical therapeutic target, nor is it known to interact with drugs; its deficiency is associated with sperm motility defects rather than broader diseases or syndromes[1][3][4].
- Other names
- Tektin bundle-interacting protein 1TEKTIP1C19orf71LOC100128569uncharacterized protein C19orf71
02
Biological functions
Sperm flagellum structural organizationStabilization of tektin bundlesRegulation of sperm motility
03
Disease associations
Male subfertility (associated with reduced sperm motility and partially disorganized axoneme in knockout mouse models)Other (potential relevance to human asthenospermia suggested but not verified)
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