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Target intelligence / Profile preview
Tektin-like protein 1 (TEKTL1)
- Target
- TEKTL1
- Molecular classification
- Other (Cytoskeletal structural protein, specifically associated with sperm flagellar microtubules)
01
Overview
Tektin-like protein 1 (TEKTL1), encoded by the CCDC105 gene, is a coiled-coil domain-containing protein believed to function as a conserved cytoskeletal component, particularly associated with the inner microtubules of sperm flagella[3]. TEKTL1 is not an enzyme, signaling receptor, or commonly drug-targeted molecule. It is distinct from "Transketolase-like protein 1 (TKTL1)," which is an unrelated metabolic enzyme with established roles in cancer, glucose metabolism, and disease[1][2][4][6]. No evidence supports a role for TEKTL1/CCDC105 in canonical disease pathways outside of its presumed structural function, and the molecule is not recognized as a therapeutic or diagnostic target.
- Other names
- Tektin-like protein 1TEKTL1CCDC105Coiled-coil domain-containing protein 105FLJ40365
02
Mechanism of action
None (for TEKTL1/CCDC105)
03
Biological functions
Unknown (for TEKTL1/CCDC105—limited evidence; some indications of structural role in sperm microtubules[3], but not established as an enzyme or signaling molecule)Sperm flagellar organization (based on homology to tektins—known components of ciliary and flagellar microtubules in sperm and other motile cells[3])
04
Disease associations
Other (No established direct role in major diseases; possible relevance to infertility through sperm flagellar defects but not therapeutically targeted)
05
Safety considerations
None established
06
Interacting drugs
None known (for TEKTL1/CCDC105; no drugs reported that target this protein)
07
Biomarkers
None known (for TEKTL1/CCDC105)
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