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Target intelligence / Profile preview
Telomerase Reverse Transcriptase Catalytic Subunit (hTERT)
- Target
- hTERT
- Molecular classification
- Enzyme, Reverse Transcriptase, Ribonucleoprotein
01
Overview
The human telomerase reverse transcriptase catalytic subunit (hTERT) is a multi-functional enzyme essential for cellular immortality mechanisms through both canonical (telomere extension) and noncanonical pathways—including mitochondrial protection—and serves as a prominent target antigen for cancer immunotherapy strategies involving helper epitopes derived from this protein. It maintains telomere length, preventing chromosomal degradation during cell division, and plays roles in stem cell maintenance, RNA polymerization, and mitochondrial protection. Deregulation of TERT is implicated in oncogenesis, making it a target for cancer therapy. Mutations can lead to genetic disorders.
- Other names
- HEST2EST2TP2TRTCMM9Telomerase catalytic subunitTelomerase-associated protein 2hEST2hTRTPFBMFT1TCS1
02
Mechanism of action
Inhibition of telomerase activity; Stimulation of anti-tumor immune response via TERT-derived peptides
03
Biological functions
Telomere maintenanceDNA replicationStem cell maintenanceCellular reprogrammingRNA-dependent RNA polymerizationMitochondrial protectionPrevention of replicative senescence
04
Disease associations
CancerGenetic Disorders (e.g., Cri du Chat syndrome)Bone marrow failure syndromesCardiovascular disease
05
Safety considerations
Potential for off-target effects in normal cells with low-level TERT expressionImmune-related adverse events associated with TERT-targeted immunotherapies
06
Interacting drugs
GV1001
07
Biomarkers
hTERT expression levels in cancer cellsTERT variants associated with cancer susceptibility
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