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Target intelligence / Profile preview
Telomere repeat-binding bouquet formation protein 1 (TERB1)
- Target
- TERB1
- Molecular classification
- Other (Meiosis-specific telomere-associated scaffold protein)
01
Overview
Telomere repeat-binding bouquet formation protein 1 (TERB1) is a meiosis-specific protein that acts as a molecular scaffold, critical for tethering telomeres to the inner nuclear membrane during prophase I of meiosis. It forms a stable complex with TERB2 and MAJIN, mediating the association of telomeric DNA (shelterin complex and TRF1) with the nuclear envelope. This NE attachment is required for homologous chromosome pairing, synapsis, and the progression of meiotic division. Disruption in TERB1 or its interacting partners abolishes telomere-NE attachment, leading to synapsis defects and infertility in mammals. TERB1 is not a classical therapeutic target such as a receptor, enzyme, or transporter, but rather a structural/organizing protein essential for reproductive cell meiosis[1][2][3].
- Other names
- Telomere repeat-binding bouquet formation protein 1TERB1CCDC79FLJ35894Coiled-coil domain-containing protein 79SPGF60
02
Biological functions
Meiotic telomere-nuclear envelope attachmentHomologous chromosome pairing during meiosisSynapsis regulationStructural scaffold for telomere complexesRecruitment of cohesin to telomeresRegulation of meiotic recombination and telomere cap exchange
03
Disease associations
Spermatogenic failure (Spermatogenic failure 60)Infertility (Azoospermia)
04
Safety considerations
Deficiency or genetic disruption leads to infertility due to meiotic failure[2][3]
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