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Target intelligence / Profile preview
Telomere repeat-binding bouquet formation protein 2 (TERB2)
- Target
- TERB2
- Molecular classification
- Other (Meiotic chromosome attachment protein), Chromosome-associated structural protein
01
Overview
Telomere repeat-binding bouquet formation protein 2 (TERB2) is a meiosis-specific, telomere-associated protein central to chromosome dynamics in germ cells. TERB2 is a component of the tripartite meiotic telomere complex (MTC), along with TERB1 and MAJIN, which is vital for the attachment of telomeres to the inner nuclear membrane during meiotic prophase I. This tethering is essential for homologous chromosome pairing, synapsis, and normal progression through meiosis. Disruption of TERB2 function, or loss-of-function mutations, abrogate telomere-nuclear envelope attachment, leading to meiotic failure, germ cell maturation arrest, and clinically, male infertility (notably non-obstructive azoospermia). TERB2 does not currently represent a therapeutic target in the contexts of pharmacology, oncology, or chemical biology, nor are any drugs known to modulate its function in clinical or preclinical settings.
- Other names
- C15orf43MGC33951SPGF59telomere repeats-binding bouquet formation protein 2
02
Biological functions
Meiotic telomere attachment to the nuclear envelopeHomologous chromosome pairing during meiosisSpermatogenesis and oogenesis (gametogenesis)
03
Disease associations
Male infertility (specifically, non-obstructive azoospermia/spematogenic failure 59)Other (defects in meiosis, maturation arrest)
04
Biomarkers
Mutations in TERB2 as a biomarker for male infertility (non-obstructive azoospermia)
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