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Target intelligence / Profile preview
Telomeric Repeat Binding Factor 2 (TRF2)
- Target
- TRF2
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
TRF2 is a key component of the shelterin complex, responsible for protecting telomeres from being recognized as DNA double-strand breaks. It promotes T-loop formation, inhibits DNA damage responses, and plays a role in genome stability and gene expression regulation. Loss or dysfunction of TRF2 can lead to telomere uncapping, genomic instability, and cellular senescence, making it relevant for research into aging and cancer.
- Other names
- TERF2TRBF2
02
Mechanism of action
N/A
03
Biological functions
Telomere maintenanceDNA damage response inhibitionT-loop formationGenome stabilityRegulation of gene expression
04
Disease associations
AgingCancerGenomic instability
05
Safety considerations
Disruption of telomere functionActivation of DNA damage responseGenomic instability
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