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Target intelligence / Profile preview
Ten-eleven Translocation Family Proteins (TET)
- Target
- TET
- Molecular classification
- Enzyme, Dioxygenase, DNA demethylase, Epigenetic regulator
01
Overview
Ten-eleven translocation family proteins are key epigenetic regulators responsible for dynamic changes in cytosine methylation status via oxidation reactions. They influence development, immune response modulation, stem cell biology, brain function, tumor suppression/promotion depending on context—and represent important targets for research into diagnostics and therapeutics across multiple disease areas.
- Other names
- TET1TET2TET3
02
Mechanism of action
Catalyzes the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). These oxidized cytosines are intermediates in DNA demethylation.
03
Biological functions
DNA demethylationEpigenetic regulationEmbryogenesisGametogenesisHematopoietic stem cell self-renewalHematopoietic stem cell differentiationMemory formationLearningAddiction responsesPain perceptionGene expression regulation
04
Disease associations
Myeloid malignanciesMyelodysplastic syndromes (MDS)Myeloproliferative neoplasmsChronic myelomonocytic leukemiaColorectal cancerHepatocellular carcinomaAcute kidney injuryChronic kidney diseaseCancer
05
Safety considerations
Off-target effects on DNA methylationPotential for disrupting normal developmentUnintended consequences on gene expression patternsReactivation of endogenous retroviruses
06
Biomarkers
5hmC levelsTET protein expression levelsMutations in TET genes
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