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Target intelligence / Profile preview
Ten-eleven translocation oncogene 2 (TET2)
- Target
- TET2
- Molecular classification
- Enzyme, Dioxygenase, Transcription factor, Histone modification
01
Overview
TET2 is a methylcytosine dioxygenase enzyme that plays a crucial role in epigenetic regulation by catalyzing the conversion of 5mC to 5hmC, a key step in DNA demethylation. It acts as a tumor suppressor, particularly in hematopoietic stem cells, influencing blood cell development and differentiation. Mutations in TET2 are associated with various hematologic malignancies and clonal hematopoiesis. Loss of function typically results in decreased levels of genomic 5hmC, making it a potential biomarker.
- Other names
- Tet methylcytosine dioxygenase 2
02
Mechanism of action
Catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA, a key step in active DNA demethylation.
03
Biological functions
Epigenetic regulationTumor suppressionHematopoiesisDNA demethylationGene expression regulation
04
Disease associations
Hematologic malignanciesClonal hematopoiesisEssential thrombocythemiaPolycythemia veraPrimary myelofibrosisCancer
05
Safety considerations
Haploinsufficiency leads to increased risk of transformation into leukemia or lymphoma-like diseases
06
Biomarkers
5hmC levels in myeloid malignancies
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