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Target intelligence / Profile preview
Tenascin C (None)
- Target
- None
- Molecular classification
- Extracellular matrix glycoprotein, Glycoprotein
01
Overview
Tenascin C is a large, multimodular extracellular matrix glycoprotein involved in embryonic development, tissue injury, inflammation, and tumorigenesis. It modulates cell adhesion, migration, proliferation, and differentiation, and plays a role in synaptic function and immune response. It is a potential therapeutic target in cancer and other diseases due to its restricted expression pattern in adults.
- Other names
- TN-CTNC
02
Mechanism of action
Varies depending on the context; includes modulation of cell adhesion and signaling pathways (FAK/MAPK/PLC)
03
Biological functions
ECM remodelingModulation of cell adhesionCell migrationCell proliferationCell differentiationRegulation of cell survivalSynaptic function modulationImmune response modulation
04
Disease associations
CancerWound healingCardiovascular diseaseInflammationStem cell regulation
05
Safety considerations
Potential for promoting tumor progression and metastasisPotential to exacerbate fibrosis if misregulated during tissue repair
06
Biomarkers
Tumor stroma marker in various cancers
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