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Target intelligence / Profile preview
Tenascin-C mRNA (TNC mRNA)
- Target
- TNC mRNA
- Molecular classification
- Messenger RNA, Extracellular matrix protein (encoded product)
01
Overview
Tenascin-C (TNC) mRNA is the messenger RNA transcript that encodes Tenascin-C, a large hexameric extracellular matrix (ECM) glycoprotein (UniProt: P24821). While Tenascin-C is essential during embryonic development, its expression in healthy adult tissues is highly restricted, appearing primarily during wound healing or in response to mechanical stress. However, TNC mRNA is significantly overexpressed in various pathological conditions, including solid tumors, chronic inflammation, and fibrotic diseases (PubMed: 30333295). In the context of oncology, the resulting protein promotes tumor cell proliferation, epithelial-mesenchymal transition (EMT), and angiogenesis, making the mRNA an attractive target for silencing therapies. Therapeutic strategies such as siRNA (e.g., STNM01) aim to degrade TNC mRNA to reduce the protein's contribution to disease progression and tissue remodeling (PubMed: 21854181).
- Other names
- TNCHXBCytotactinNeuronectinGMEMJIMiotactinGP 150-225
02
Mechanism of action
RNA interference (RNAi) leading to the sequence-specific degradation of Tenascin-C mRNA, thereby inhibiting the synthesis of the Tenascin-C protein (PubMed: 21854181).
03
Biological functions
Modulation of cell-matrix adhesionPromotion of cell migrationRegulation of cell proliferationInduction of pro-inflammatory cytokinesAngiogenesisTissue remodeling
04
Disease associations
Esophageal cancerCrohn's diseaseGlioblastomaBreast cancerMyocardial infarctionPulmonary hypertensionFibrosis
05
Safety considerations
Potential impairment of physiological wound healing (PubMed: 30333295)Off-target silencing effects of RNAiInnate immune activation by synthetic RNA oligonucleotidesChallenges in systemic delivery to target tissues
06
Interacting drugs
STNM01
07
Biomarkers
TNC mRNA expression levels in biopsyTenascin-C protein levels in tissueSerum Tenascin-C concentration
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