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Tenascin XA pseudogene (TNXA)

Target: TNXA
Molecular classification: Other (pseudogene)

Overview

TNXA is a **non-coding pseudogene** located within the major histocompatibility complex (MHC) class III region on chromosome 6. It is a product of gene duplication and is homologous to the functional gene *TNXB*, which encodes the extracellular matrix protein tenascin-X. Unlike *TNXB*, TNXA is incomplete and does not produce a functional protein product. The existence of TNXA and its high homology to TNXB can mediate recombination events that are clinically relevant, notably leading to gene rearrangements that may result in pathologies such as congenital adrenal hyperplasia due to *CYP21A2* recombination, but TNXA itself is not a protein, receptor, or therapeutic target[3][1].

Other names: Putative tenascin-XATNXAXATN-XAD6S103EHXBL

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