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Tendon tissue regeneration refers to the complex biological process by which tendon tissue undergoes repair or replacement following injury. This process involves distinct phases: inflammation, proliferation, and remodeling, coordinated by the activity of various cell types (notably tenocytes and tendon progenitor/stem cells), growth factors, and the extracellular matrix. Approaches to enhance tendon tissue regeneration commonly employ tissue engineering strategies—combining cellular therapies (e.g., stem cells), scaffolds, and biologics—to facilitate proper healing and restore biomechanical function. Unlike a specific molecule or receptor, 'tendon tissue regeneration' describes a therapeutic objective and encompasses multiple molecular and cellular targets within orthopedic and regenerative medicine.
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