Teneurin transmembrane protein 2 (TENM2)

Teneurin transmembrane protein 2 (TENM2) is a large cell-surface adhesion protein essential for proper neural development, particularly in regulating axon guidance, neuronal migration, and synaptic connectivity in the central nervous system[1][2][3]. TENM2 is a type II transmembrane protein, containing an N-terminal cytoplasmic region, a single transmembrane span, and a large, structurally complex extracellular region with EGF-like repeats, an immunoglobulin-like domain, and a toxin-like β-barrel domain[1][3]. It functions as a ligand for the latrophilin family of transmembrane GPCRs (particularly ADGRL1 and ADGRL3), mediating heterophilic cell-cell adhesion and facilitating retrograde synaptic signaling[1][2][3]. TENM2 is broadly expressed across neuronal and other tissues and has been linked to various neural developmental processes and disease phenotypes, although it is not yet a direct clinical drug target. Its multi-domain architecture and regulated splicing underlie diverse roles in embryogenesis, signal transduction, and tissue patterning[1][3][2].

Other names

Teneurin-2Ten-2TEN2ODZ2KIAA1127Ten-m2Ten-2 ICDTen-M2TNM2neurestin alphaodd Oz/ten-m homolog 2protein Odd Oz/ten-m homolog 2tenascin-M2

Not established due to lack of known interacting drugs. Potential mechanism: modulation of cell-cell adhesion, synaptic formation, or axon guidance by targeting TENM2's extracellular domains or its interaction with latrophilin-type GPCRs