Teneurin transmembrane protein 4 (TENM4)

Teneurin transmembrane protein 4 (TENM4) is a large, evolutionary conserved, single-pass type II transmembrane protein predominantly expressed in the nervous system. It is a member of the teneurin family of cell adhesion molecules crucial for neural development, mediating cell-cell and synaptic interactions, and axon guidance. Structurally, TENM4 possesses domains such as EGF-like, YD repeats, and beta-propeller, contributing to its adhesive and signaling functions. TENM4 regulates neurodevelopmental processes, including synaptic partner matching and oligodendrocyte differentiation, and its loss of function is associated with defects in neuronal connectivity and hereditary essential tremor 5. In cancer, TENM4 is recurrently rearranged or fused with genes such as NRG1 to generate oncoproteins (e.g., γ-heregulin), and its expression can be epigenetically regulated. There is emerging evidence of its role in multiple cancer types, but it is not a current therapeutic drug target, nor are drugs specifically known to modulate its function[1][2][3][4][5][6].

Other names

Teneurin-4ODZ4KIAA1302DOC4Protein Odd Oz/ten-m homolog 4Tenascin-M4downstream of CHOP 4Ten-4Ten-M4TNM4ETM5Ten-m4odz