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Target intelligence / Profile preview
Teratocarcinoma-derived growth factor 1 (TDGF1)
- Target
- TDGF1
- Molecular classification
- Growth Factor, GPI-anchored cell membrane protein, Co-receptor, Co-ligand
01
Overview
Teratocarcinoma-derived growth factor 1 (TDGF1), also known as Cripto, is a GPI-anchored cell membrane protein that functions as a co-receptor and co-ligand for the TGF-beta family member Nodal in embryonic signaling pathways. It plays a critical role in mesoderm induction during gastrulation and stem cell maintenance. TDGF1 is overexpressed in various cancers and is implicated in tumor growth and metastasis. Mutations can cause forebrain defects such as holoprosencephaly.
- Other names
- CriptoCRIPTOCripto-1CRIPTO-1CFC-2CRGF
02
Mechanism of action
Acts as a co-receptor and co-ligand for Nodal, modulating TGF-beta signaling.
03
Biological functions
Nodal signalingEmbryogenesis (mesoderm induction)Stem cell maintenanceCell proliferationCell signaling
04
Disease associations
CancerForebrain defects (holoprosencephaly)Developmental disorders
05
Safety considerations
Overexpression implicated in tumor growth and metastasisEssential role in embryonic development means targeting must be carefully considered.
06
Biomarkers
TDGF1 overexpression in certain cancers
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