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Target intelligence / Profile preview
TERF1-interacting nuclear factor 2 (TINF2)
- Target
- TINF2
- Molecular classification
- Other (shelterin complex component, chromatin-associated architectural protein)
01
Overview
TERF1-interacting nuclear factor 2 (TINF2) encodes a core, non-enzymatic component of the shelterin complex, a multi-protein assembly that binds telomeres and protects chromosome ends from being recognized as DNA damage. TINF2 (TIN2) acts as an architectural bridge, directly interacting with three key telomeric DNA-binding proteins—TRF1, TRF2, and the TPP1/POT1 heterodimer—ensuring the integrity and function of the shelterin complex and thereby maintaining telomere stability. Germline mutations in TINF2 impair this function, leading to telomere shortening and various telomere biology disorders, such as dyskeratosis congenita and related syndromes, as well as a predisposition to malignancy. TINF2 itself is not currently a direct therapeutic target for small-molecule drugs or biologics.
- Other names
- TIN2TRF1-interacting nuclear protein 2DKCA3DKCA5TERF1 (TRF1)-interacting nuclear factor 2shelterin component TIN2
02
Biological functions
Maintenance of telomere structure and lengthProtection of chromosome endsAssembly and regulation of the shelterin complexRegulation of telomere DNA repair pathways
03
Disease associations
Telomere biology disorders (including dyskeratosis congenita, Revesz syndrome, Hoyeraal-Hreidarsson syndrome)Bone marrow failure syndromesCancer risk (notably increased risk with loss-of-function mutations)
04
Safety considerations
Mutations can cause telomere dysfunction, bone marrow failure, and increased cancer susceptibility
05
Biomarkers
TINF2 mutations (for diagnosis of dyskeratosis congenita and other telomere biology disorders)
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