Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Terminal nucleotidyltransferase 4A
- Molecular classification
- Enzyme, Terminal Nucleotidyltransferase
01
Overview
Terminal nucleotidyltransferase 4A (TENT4A), also known as PAPD7, is a non-canonical poly(A) polymerase that catalyzes the addition of ATP and GTP to the 3' end of RNA molecules, creating heterogeneous poly(A) tails. It plays a role in mRNA stability, DNA-damage tolerance, and has been implicated in diseases such as endometrial cancer and dyskeratosis congenita. Inhibition of PAPD5/7 can rescue telomerase function, suggesting its involvement in telomere maintenance and stem cell biology.
- Other names
- TENT4APAPD7
02
Mechanism of action
Inhibition of PAPD5/7 has shown promise in rescuing telomerase function.
03
Biological functions
mRNA stability modulationDNA damage responseNon-canonical polyadenylationPolyguanylationRNA metabolic processes
04
Disease associations
CancerEndometrial cancerTelomere disordersDyskeratosis congenita
Beyond the preview
Go deeper on Terminal nucleotidyltransferase 4A.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Terminal nucleotidyltransferase 4A.