Terminal uridylyltransferase 7 (TUT7)

Terminal uridylyltransferase 7 (TUT7) is a cytoplasmic enzyme encoded by the ZCCHC6 gene in humans. It belongs to the family of non-canonical terminal nucleotidyltransferases and catalyzes the template-independent addition of uridine residues to the 3' end of RNA substrates, specifically targeting mRNAs with short poly(A) tails and certain precursor microRNAs (pre-miRNAs). TUT7 plays a central role in regulating the stability and maturation of mRNA and miRNA molecules by: - Promoting mRNA degradation via 3′ uridylation, targeting transcripts with short poly(A) tails for decay[1]. - Mediating the biogenesis of let-7 and other microRNAs; for group II pre-miRNAs with a 1-nt 3′ overhang, TUT7 monouridylates to facilitate Dicer processing and maturation; for aberrant or trimmed pre-miRNAs, TUT7 adds oligo(U) tails, marking them for degradation[3][4][5]. - Participating in innate immune responses by modulating mRNA stability of inflammatory mediators downstream of TLR4 signaling[2]. TUT7 acts redundantly or synergistically with TUT4, especially in miRNA biogenesis, and can be implicated in diseases involving alteration in RNA metabolism, inflammation, or miRNA-regulated gene networks[5].

Other names

Zinc finger CCHC domain-containing protein 6ZCCHC6TUTase 7PAP associated domain containing 6PAPD6TENT3BHS2KIAA1711FLJ13409