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Target intelligence / Profile preview
Testes-specific protease 50 (TSP50)
- Target
- TSP50
- Molecular classification
- Serine protease, Cancer/testis antigen, Tumor-associated antigen
01
Overview
Testes-specific protease 50 (TSP50) is a serine protease normally expressed in the testes but aberrantly overexpressed in various human cancers, including breast, colorectal, gastric, and prostate cancers. It promotes cell proliferation, invasion, and metastasis through activation of the NF-κB signaling pathway. High expression levels correlate with advanced disease stage and poor prognosis, making it an attractive biomarker and potential therapeutic target.
02
Mechanism of action
Inhibition of NF-κB signaling pathway
03
Biological functions
Cell proliferationEpithelial-mesenchymal transition (EMT)Apoptosis regulationNF-κB signaling pathway activation
04
Disease associations
Cancer
05
Safety considerations
Potential on-target toxicity in testicular tissue
06
Biomarkers
TSP50 protein expression level in tumor tissue
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