Testicular spindle-associated protein SHCBP1L (SHCBP1L)

Testicular spindle-associated protein SHCBP1L (SHCBP1L) is a conserved, predominantly testis-specific protein found in mammals and encoded by the SHCBP1L gene on human chromosome 1. The protein binds heat shock 70 kDa protein 2 (HSPA2) and plays an essential role in stabilizing the spindle apparatus during meiosis, enabling proper spermatogenesis in male germ cells. Loss of SHCBP1L disrupts meiotic progression and causes apoptosis in spermatocytes, resulting in male subfertility. The gene is situated within a chromosomal region linked to prostate cancer susceptibility, though its direct involvement in cancer or other diseases is limited to disease associations identified in genetic studies. SHCBP1L is not a therapeutic target, drug target, biomarker, or subject to drug safety concern as of now, but its essential role in male fertility may warrant continued study in reproductive biology and disease genetics

Other names

SHC SH2-domain binding protein 1-likeC1orf14GE36SHCBP1LpQ9BZQ2hSHCBP1L

None known (no drugs or modulators acting on SHCBP1L have been described; mechanisms of action for drugs are not applicable at present)