Testin LIM domain protein (TES)

Testin LIM domain protein is a cytoskeletal scaffold and signaling integrator found at focal adhesions and along actin stress fibers, encoded by the TES gene. It is characterized by three C-terminal LIM domains and a PET domain, allowing for versatile protein-protein associations. Testin promotes cell adhesion, cytoskeleton maintenance, and suppresses tumorigenesis. It is mainly studied in cancer biology, as its loss leads to disrupted cell structure and increased metastatic capacity. Testin interacts with zyxin, actin, MENA (ENAH), VASP, alpha-actinin, paxillin, talin, ALKBH4, GRIP1 and other focal adhesion partners, mediating its function as a tumor suppressor[1][5][6][7].\n\nTestin LIM domain protein is not a classic receptor, enzyme, transporter, or transcription factor, but belongs to the LIM domain scaffold/cytoskeletal regulators, and is characterized primarily as a tumor suppressor with important roles in cellular structure, adhesion, and cancer pathophysiology[1][2][5][6].

Other names

TESTESSTESS-2TESTIN

No drugs directly targeting TES; hypothetical/experimental mechanisms would involve mimicking TES's interaction with MENA to inhibit cancer cell motility[1].