Testis anion transporter 1 (SLC26A8)

Testis anion transporter 1 (SLC26A8) is a transmembrane protein encoded by the SLC26A8 gene, highly and specifically expressed in male germ cells—especially spermatocytes[1][3][5]. It is a member of the solute carrier (SLC) 26 family of anion transporters and mediates the exchange of multiple anions, most notably chloride, sulfate, bicarbonate, and oxalate across the plasma membrane[1][5]. SLC26A8 is localized primarily to the sperm flagellum and is critical for normal sperm motility, capacitation, and structural integrity of the sperm tail and annulus[1][2][5]. The protein physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator (CFTR), a relationship essential for activating CFTR-dependent Cl^- and HCO₃⁻ fluxes required for the PKA-dependent phosphorylation cascades that underlie sperm motility and capacitation[1][2][4][7]. Mutations in SLC26A8, particularly compound heterozygous variants, have been related to male infertility characterized by asthenozoospermia (reduced sperm motility) and structural sperm abnormalities; however, not all variants are pathogenic, and a clear genotype-phenotype link can be complex[5]. SLC26A8 does not currently have known therapeutic drugs or interventions targeting it directly. Its clinical significance is primarily as a mechanism for idiopathic male infertility and a potential biomarker for certain infertility phenotypes[5].

Other names

SLC26A8TAT1Anion exchange transporterSolute carrier family 26 member 8Testis anion transporter 1AZONSPGF3Anion transporter/exchanger-8Solute carrier family 26 (anion exchanger), member 8

Not applicable (no drugs identified targeting SLC26A8)