Target intelligence / Profile preview

Testis-expressed protein 10 (TEX10)

Target: TEX10
Molecular classification: Chromatin-associated protein, Regulatory protein (transcriptional/epigenetic modulator), Component of multiprotein complexes (e.g., rixosome, 5FMC complex)

Overview

Testis-expressed protein 10 (TEX10) is a chromatin-associated nuclear protein highly expressed in testis, embryonic stem cells, and primordial germ cells. It is essential for ESC pluripotency, preimplantation development, and spermatogenesis, acting through transcriptional regulation of genes involved in germ cell differentiation and maturation. TEX10 coordinates super-enhancer activity and epigenetic modification by recruiting histone acetyltransferase p300 and DNA demethylase Tet1, contributing to the pluripotency network in ESCs, and interacts with Sox2 for enhanceosome assembly. Deficiency in TEX10 disrupts chromosomal segregation and maturation of sperm, leading to male infertility. It is a component of multiprotein complexes such as the rixosome (involved in ribosome biogenesis) and the Five Friends of Methylated CHTOP (5FMC) complex. Ongoing research highlights TEX10 as a potential therapeutic target for treating male infertility and in regenerative medicine settings.

Other names: TEX10Testis-expressed protein 10L18Nbla10363FLJ20287bA208F1.2Ipi1testis-expressed gene 10testis-expressed sequence 10 protein

Mechanism of action

Not applicable (no drugs identified targeting this molecule directly)

Biological functions

Regulation of stem cell pluripotency (pluripotency factor)Epigenetic regulation (modulates histone acetylation, DNA demethylation)Transcriptional control of germ cell development and spermatogenesisRegulation of Wnt signaling via chromatin occupancyAssembly of the enhanceosome for super-enhancer activity in ESCsRibosome biogenesis (as part of the rixosome complex)

Disease associations

Male infertility (critical for spermatogenesis; deficiency leads to meiotic arrest and round spermatid failure)Possible roles in stem cell-related pathologies and cancer, due to pluripotency regulationOther (may be relevant for regenerative medicine and developmental disorders)

Safety considerations

Targeting TEX10 may affect pluripotency and germ cell development, raising concerns about off-target effects on fertility and tissue regenerationNo known safety issues related to direct drug targeting, as no drugs currently exist

Biomarkers

Potential biomarker in male infertility (expression and activity could indicate spermatogenic competence)Potential marker for ESC pluripotency or differentiation states

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