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Target intelligence / Profile preview
Testis-expressed protein 13D (TEX13D)
- Target
- TEX13D
- Molecular classification
- Other (Testis-specific protein, likely a transcription cofactor/RNA binding protein, not classified under GPCR, ion channels, receptors, enzymes, or transporters), Possible zinc-finger protein (contains a zinc finger-RANBP2-like domain), Protein coding gene
01
Overview
Testis-expressed protein 13D (TEX13D) is a member of the TEX13 family, a group of proteins expressed almost exclusively in the male germ cells of mammals. TEX13D is predicted to act as a transcriptional cofactor and repressor, possibly via its zinc finger domain, and has developmentally regulated testis-specific expression. Unlike other family members, there is no evidence of TEX13D being essential for male fertility (mouse knockouts have normal fertility). Rare genetic variants in TEX13D have been observed in association with certain forms of spermatogenic failure, but its role as a disease gene remains uncertain due to lack of linked causality in validation studies. The protein's key features are mRNA binding, transcriptional repression, and nuclear localization in mature sperm. No drugs, biomarkers, or safety concerns are reported related to TEX13D, and it is not considered a therapeutic target in current medicine or pharmacology.
- Other names
- TEX13 family member DTestis-expressed protein 13DTX13DTEX13D
02
Mechanism of action
None identified (not an established drug target)
03
Biological functions
Transcriptional repression (acts as a transcriptional repressor/cofactor)RNA binding (predicted mRNA binding activity)Metal ion binding (predicted)Regulation of spermatogenesis (developmentally regulated expression in male germ cells)
04
Disease associations
Other (specifically, some diseases associated with TEX13D include Spermatogenic Failure 23 and Spermatogenic Failure 25)The gene is not linked to common diseases like cancer, inflammation, or neurodegenerative disorders in current literature
05
Safety considerations
None reported (not a therapeutic target)
06
Interacting drugs
None identified
07
Biomarkers
None established
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