Testis-specific protein Y-encoded (TSPY)

Testis-specific protein Y-encoded (TSPY) is a member of the *ampliconic gene family* on the human Y chromosome, expressed predominantly in testicular germ cells[1][2]. It plays a role in germ cell development and has been shown to act as a repressor of androgen receptor (AR)-mediated signaling, particularly in the context of testicular germ cell tumors (TGCTs), where it interacts with and sequesters androgen-bound AR in the cytosol, thereby suppressing androgen-dependent cell proliferation. While TSPY itself has been implicated in gonadoblastoma and can serve as a marker for TGCT malignancy, it is not a recognized therapeutic target and there are no drugs known to specifically interact with it. Important aliases include TSPY1 (canonical gene), TSPY3, Cancer/testis antigen 78 (CT78), and Testis-specific Y-encoded protein 3. Note: There is *no evidence* in current authoritative databases (UniProt, OMIM, GeneCards) for a distinct gene or protein called "TSPY10"—this appears to be a misnomer, conflation of family members, or erroneous naming. Information provided applies to the *TSPY* gene/protein and its primary isoforms with known function[1][2][3]. **Important clarification:** - "TSPY10" is not recognized as a valid or distinct gene/protein entry in human genome annotation resources. All synonyms provided in the query correspond to TSPY/TSPY1 (also known simply as TSPY or Testis-specific protein Y-encoded)[3]. There appears to be no peer-reviewed literature specifically describing "TSPY10" as a gene or protein. Therefore, this entry is marked "is_incorrect: true" due to nomenclature error or database misannotation. References: - *Function* and *disease* information are derived from testicular germ cell tumor research and testis expression data[1]. - *Classification* is based on protein structure and gene family[2]. - Nomenclature clarification comes from major gene/protein databases[3]. [1] [2] [3]

Other names

Testis-specific protein Y-encodedTSPYTSPY1TSPY3Cancer/testis antigen 78CT78

Not established for any therapeutic drugs; endogenous function includes repression of androgen receptor-mediated transcription[1]