Testis-specific Y-encoded-like protein 5 (TSPYL5)

Testis-specific Y-encoded-like protein 5 (TSPYL5) is a member of the TSPY-like protein family with a nucleosome assembly protein (NAP)-like domain, predominantly characterized as an intrinsically disordered protein[2]. TSPYL5 localizes to both nucleus (notably nucleolus) and cytoplasm, with localization governed by distinct sequence motifs. The protein functions as a chaperone for histones and ribosomal proteins, may participate in chromatin remodeling, and is implicated in regulating transcription, cell growth, and stress responses. Notably, TSPYL5 interacts with the tumor suppressor p53, modulating its ubiquitination, sumoylation, and cellular localization—thus potentially promoting oncogenic processes in cancers exhibiting cytoplasmic sequestration of p53[5]. TSPYL5 has emerging relevance as a marker and possible therapeutic target in oncology, though no current drugs directly target it[2][4][5].

Other names

TSPY like 5KIAA1750TSPY-like protein 5testis-specific Y-encoded-like protein 5

Not determined for drugs; mechanistically, TSPYL5 modulates cell growth, p53 function, and AKT pathway signaling, suggesting possible mechanisms for future therapeutics[4][5].