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Target intelligence / Profile preview
Testis-specific Y-encoded protein 1 (TSPY1)
- Target
- TSPY1
- Molecular classification
- Other, SET/NAP family, Cancer/testis antigen
01
Overview
Testis-specific Y-encoded protein 1 (TSPY1) is a member of the SET/NAP (TTSN) superfamily, encoded by a multicopy gene on the human Y chromosome and expressed predominantly in adult human spermatogonia[1][4][6]. It functions primarily in spermatogenesis, promoting spermatogonial proliferation via regulation of the cell cycle, suppression of USP7-mediated p53 function, maintenance of spermatogonial homeostasis, and chromatin remodeling[1][4]. TSPY1 acts as a cancer/testis antigen, is strongly upregulated in gonadoblastoma and certain cancers (testis, prostate, liver), and may contribute to tumorigenesis when aberrantly expressed in somatic tissues[1][5][6]. Copy number variations of TSPY1 are associated with male infertility and cancer susceptibility[1].
- Other names
- Testis-specific protein Y-linked 1TSPYDYS14pJA923CT78cancer/testis antigen 78Cancer/testis antigen 78
02
Mechanism of action
Regulation of cell cycle progression (G2/M phase transition) via suppression of USP7-mediated p53 function, Promotion of cell proliferation, Control of apoptosis through ubiquitin-mediated degradation of p53
03
Biological functions
Cell cycle regulationChromatin remodelingSpermatogenesisCell proliferationApoptosis regulationTranscription modulation
04
Disease associations
CancerGonadoblastomaTesticular cancerProstate cancerMale infertility
05
Safety considerations
Ectopic expression linked to tumorigenesisCopy number imbalance can disrupt spermatogenesisPotential oncogenicity if aberrantly activated outside testis
06
Biomarkers
TSPY1 overexpression (biomarker for gonadoblastoma and testicular germ cell tumors)Used in Y chromosome microdeletion diagnostics
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