Target intelligence / Profile preview

Clostridium tetani neurotoxin (TeNT)

Target: TeNT
Molecular classification: Neurotoxin, Endopeptidase

Overview

Clostridium tetani neurotoxin (TeNT), also known as tetanus toxin, is a potent neurotoxin produced by Clostridium tetani. It causes tetanus by inhibiting neurotransmitter release from inhibitory interneurons in the central nervous system, leading to spastic paralysis.

Other names: Tetanus toxinTetanospasminTentoxylysin

Mechanism of action

The light chain cleaves synaptobrevin/VAMP2, blocking neurotransmitter release from inhibitory interneurons, leading to unopposed muscle contraction and spastic paralysis.

Biological functions

Inhibition of neurotransmitter releaseCleavage of synaptobrevin/VAMP2

Disease associations

Tetanus

Safety considerations

Extreme potency as a neurotoxinCauses spastic paralysis and death

Beyond the preview

Go deeper on Clostridium tetani neurotoxin (TeNT).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Clostridium tetani neurotoxin (TeNT).

Explore the full profile