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Target intelligence / Profile preview
Tetanus Toxin Fragment C (TTFC)
- Target
- TTFC
- Molecular classification
- Toxin Fragment, Antigen
01
Overview
Tetanus toxin fragment C (TTFC) is a non-toxic, highly immunogenic polypeptide derived from the carboxy-terminal portion of the heavy chain of tetanus neurotoxin produced by Clostridium tetani. It retains the neuronal binding properties of the full-length toxin but lacks its enzymatic and toxic activities, making it suitable for use as a vaccine antigen and carrier protein. TTFC binds specifically to sialic acid-containing gangliosides on neuronal cell surfaces and induces a strong immune response without causing toxicity.
- Other names
- Tetanus toxin C-fragmentFragment C of tetanus toxinTTc
02
Mechanism of action
Induction of neutralizing antibodies and T-cell responses against tetanus toxin.
03
Biological functions
Neuronal BindingImmune Response InductionAntigen PresentationRetrograde Transport
04
Disease associations
Tetanus (prevention via vaccination)
05
Safety considerations
Potential for allergic reactionsRare neurological complications (as with any vaccine)
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