Target intelligence / Profile preview

Tetanus Toxin Protein (TeNT)

Target: TeNT
Molecular classification: Enzyme, Toxin, Metalloprotease

Overview

Tetanus toxin (TeNT) is a potent neurotoxin produced by Clostridium tetani. It functions by inhibiting neurotransmitter release, causing spastic paralysis. While toxic in its native form, detoxified forms (tetanus toxoid) are widely used as carrier proteins in conjugate vaccines due to their strong immunogenicity and ability to elicit T-cell help for conjugated antigens.

Other names: TentoxylysinTetanus toxinTetanus neurotoxin

Mechanism of action

Zinc endopeptidase that cleaves synaptobrevin-2 (VAMP)

Biological functions

Neurotransmission inhibitionVAMP cleavageCarrier protein (in vaccines)

Disease associations

TetanusInfection

Safety considerations

High toxicityPotential for spastic paralysis

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