Tetanus Toxoid Protein (TT)

Tetanus toxoid protein is an inactivated (toxoided) form of the tetanus toxin, used primarily as a vaccine antigen and as a carrier protein in conjugate vaccines. The toxoid is produced by treating the native tetanus toxin with formaldehyde, rendering it non-toxic while retaining its strong immunogenic properties. It induces robust antibody responses that neutralize circulating toxin upon exposure. TT is widely used as a carrier protein for polysaccharide-protein conjugate vaccines (e.g., Hib-TT) enhancing immune responses against otherwise poorly immunogenic antigens. Each manufacturer uses proprietary methods for detoxification and purification; thus TT preparations are not uniform across sources. Aggregation can occur with age or improper storage.

Other names

Tetanus toxoidTT toxoidrTTHc (Fragment C)Tetanus toxin (inactivated)

Induces neutralizing antibodies against tetanus toxin through B cell and T cell activation following toxoid administration.