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Tetrahydrodeoxycorticosterone (THDOC)
- Target
- THDOC
- Molecular classification
- Neurosteroid, Steroid hormone
01
Overview
Tetrahydrodeoxycorticosterone (THDOC) is an endogenous neurosteroid derived from deoxycorticosterone. It is synthesized in the brain and adrenal glands and acts as a potent positive allosteric modulator of GABA_A receptors, conferring sedative, anxiolytic, and anticonvulsant effects. THDOC levels fluctuate during stress and hormonal changes, and are implicated in various neurological and psychiatric conditions.
- Other names
- Allotetrahydrocorticosterone21-HydroxyallopregnanoloneTETRAHYDRO DOCDeoxytetrahydrocorticosterone3α,21-dihydroxy-5α-pregnan-20-one
02
Mechanism of action
Positive allosteric modulation of GABA_A receptors, enhancing GABAergic neurotransmission.
03
Biological functions
Positive allosteric modulator of GABA_A receptorsRegulation of gene expression (via progesterone receptor after conversion)
04
Disease associations
Catamenial epilepsyPremenstrual syndromeMajor depressionAnxiety disordersPTSD-like conditionsStress-sensitive brain disorders
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