Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tetrapeptide repeat homeobox 1 (TPRX1)
- Target
- TPRX1
- Molecular classification
- Transcription factor, Homeobox gene family, PRD-class homeodomain protein
01
Overview
Tetrapeptide repeat homeobox 1 (TPRX1) is a protein encoded by the TPRX1 gene in humans. It is a member of the homeobox-containing transcription factors, characterized by the DNA-binding homeodomain. TPRX1 is required immediately after fertilization for the activation of the zygotic genome, a key developmental event where gene expression transitions from maternal to embryonic control. It binds specifically to DNA sequences and regulates the transcription of key marker genes, including NANOGNB, ZSCAN4, DUXB, KLF5, and DPPA3, which are involved in early embryonic developmental programs. TPRX1 is not classified as a receptor, enzyme, or typical therapeutic target, and no drugs are currently known to act on it.
- Other names
- TPRX1TPRXTetra-peptide repeat homeobox protein 1FLJ40321CRX like homeobox 2Tetrapeptide repeat homeobox 1
02
Biological functions
Zygotic genome activation (ZGA)Early embryonic developmentSequence-specific DNA bindingRegulation of gene expression after fertilization
03
Disease associations
Disease associations are rare; some links reported with congenital muscular dystrophy-dystroglycanopathy type A5Not broadly implicated in cancer, inflammation, neurodegenerative, cardiovascular, or infectious disease
Beyond the preview
Go deeper on Tetrapeptide repeat homeobox 1 (TPRX1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tetrapeptide repeat homeobox 1 (TPRX1).