Tetrapeptide repeat homeobox-like (TPRXL)

Tetrapeptide repeat homeobox-like (TPRXL) is a human gene considered a member of the homeobox gene family, encoding a putative DNA-binding protein with a homeodomain[1][3][5]. The gene is denoted as a **pseudogene**, meaning it is widely *thought not to code for a functional protein* in humans[3][6]. It has been characterized alongside functional homeobox genes, which typically play roles in transcriptional regulation during early development, including zygotic genome activation[3][8]. However, unlike its paralog TPRX1, there is *no conclusive evidence* that the TPRXL locus encodes an active protein or is a therapeutic target. At least one report identified TPRXL as a potential biomarker in myelodysplastic syndrome, but this has not been broadly validated[7]. **Key notes:** - TPRXL is a **pseudogene**; its product is likely non-functional in most if not all humans[3][6]. - Not considered a therapeutic target such as receptor, enzyme, or transporter[3][6]. - Lists as a putative transcription factor are due to sequence homology, not demonstrated activity[3][1]. - No known interacting drugs, mechanisms of action, or associated safety concerns. - Some aliases or alternative identifiers may refer to earlier classifications or predictions, but current annotations consistently list as a pseudogene[3][6]. - Its close paralog, TPRX1 (Tetrapeptide repeat homeobox 1), *is* a protein-coding gene with established transcription factor functions[2]. If you are looking for a functional homeobox transcription factor, TPRX1 may be the intended target rather than TPRXL.

Other names

TPRXLTPRX3Ptetra-peptide repeat homeobox-likeFLJ35107