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Tetraspanin-13 (TSPAN13)
- Target
- TSPAN13
- Molecular classification
- Tetraspanin, Transmembrane protein, Cell surface protein, Membrane protein
01
Overview
Tetraspanin-13 is a cell-surface protein encoded by the TSPAN13 gene in humans and is part of the tetraspanin (transmembrane 4 superfamily) family, characterized by four transmembrane domains[1][4][6][7]. Tetraspanins function as organizers of membrane microdomains and mediate signal transduction, playing key roles in cell development, activation, growth, and motility[1][2][4]. Tetraspanin-13 has been shown to specifically interact with and regulate the function of N-type voltage-gated calcium channel CaV2.2 in neuronal tissues, modulating channel activation and inactivation, which suggests a putative role in neurotransmitter release regulation[3][5]. In addition, Tetraspanin-13 has been implicated in cancer progression, with altered levels correlated to aggressive cancer phenotypes and evidence that its knockdown promotes apoptosis and reduces proliferation in cancer cell lines[1].
- Other names
- Tspan-13Tetraspan NET-6Transmembrane 4 superfamily member 13NET6TM4SF13UNQ260/PRO296
02
Biological functions
Signal transductionCell developmentCell activationCell growthCell motilityCell proliferationRegulation of voltage-gated calcium channel activity
03
Disease associations
CancerPossible roles in neurological functions (via calcium channel regulation)
04
Safety considerations
Potential oncogenic role if dysregulated (associated with proliferation and apoptosis in cancer)
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