Tetraspanin-17 (TSPAN17)

Tetraspanin-17 (TSPAN17) is a member of the tetraspanin (transmembrane 4 superfamily) proteins, characterized by four highly conserved transmembrane domains and typically 22–39 kDa in size[1][4]. The gene encodes a protein that is part of the TspanC8 subgroup, which can interact with and regulate the trafficking, maturation, and substrate specificity of the metalloprotease ADAM10[1]. By interacting with ADAM10, TSPAN17 likely influences the expression of cell-surface molecules such as VE-cadherin and may facilitate processes like leukocyte transmigration in endothelial cells[1]. The precise biological roles and clinical significance of TSPAN17 remain incompletely defined, though similar tetraspanins are known to organize membrane complexes, modulate partner protein function, and regulate signal transduction[2][4]. Associations with autoimmune atherosclerosis have been reported, but specific drug interactions, mechanisms of action, or biomarker roles are not established[1].

Other names

Tetraspanin 17FBXO23TM4SF17Tspan-17F-box only protein 23Tetraspan protein SB134Transmembrane 4 superfamily member 17FBX23