Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tetratricopeptide repeat and ankyrin repeat-containing protein 1 (TRANK1)
- Target
- TRANK1
- Molecular classification
- Other, Protein containing tetratricopeptide (TPR) and ankyrin repeat motifs
01
Overview
Tetratricopeptide repeat and ankyrin repeat-containing protein 1 (TRANK1) is a large human protein characterized by the presence of both tetratricopeptide repeats (TPRs) and ankyrin repeats, which are structural motifs facilitating protein–protein interactions and scaffolding roles within multiprotein complexes[6][1][3]. The gene encoding TRANK1 resides on chromosome 9 and is conserved across various vertebrates. TRANK1 is thought to be involved in functions related to brain development and neuronal signaling, with genetic variants influencing susceptibility to psychiatric disorders such as bipolar disorder and schizophrenia[6]. While its biological role centers on protein–protein interaction through its repeat domains, detailed mechanistic understanding and disease-modifying potential remain active research areas. TRANK1 currently has no known direct drug interactions, established biomarker applications, or validated therapeutic targeting.
- Other names
- LBA1Lupus brain antigen 1Lupus brain antigen 1 homologKIAA0342TPR and ankyrin repeat-containing protein 1
02
Biological functions
Protein-protein interaction scaffoldingStructural stability within multiprotein complexesPossible involvement in brain developmentPotential participation in synaptic transmission
03
Disease associations
Neuropsychiatric disorders (associations with bipolar disorder, schizophrenia, and potentially other psychiatric or neurodevelopmental conditions)
Beyond the preview
Go deeper on Tetratricopeptide repeat and ankyrin repeat-containing protein 1 (TRANK1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tetratricopeptide repeat and ankyrin repeat-containing protein 1 (TRANK1).