Tetratricopeptide repeat domain 13 (TTC13)

Tetratricopeptide repeat domain 13 (TTC13) is a protein-coding gene in humans, encoding a protein with multiple tetratricopeptide repeat (TPR) motifs[1][4][8]. These repeats are short structural motifs involved in protein–protein interactions and often participate in the assembly of multiprotein complexes and scaffolding functions[3][8]. While the broader TTC (tetratricopeptide repeat-containing) family mediates important cell functions such as protein transport, complex formation, and, in some cases, cilia formation, direct biological functions and molecular partners of TTC13 remain poorly characterized[2]. No confirmed enzymatic activities, receptor activities, or roles in central cellular signaling pathways have been assigned to TTC13. The gene is occasionally associated in genetics resources with disorders such as Wilson-Turner syndrome, but its mechanistic involvement is unproven. There are no drugs or clinical biomarkers known for this protein. Tetratricopeptide repeat domain 13 (TTC13) is a human scaffold/adaptor protein with TPR motifs, facilitating protein–protein interactions. It is non-enzymatic, non-receptor, and not described as a therapeutic target, with limited disease association or functional data[1][4][8].

Other names

Tetratricopeptide repeat protein 13TTC13PSEC0076TPR repeat protein 13FLJ22584BC017545Epididymis secretory sperm binding protein (low-frequency)