Tetratricopeptide repeat domain 14 (TTC14)

Tetratricopeptide repeat domain 14 (TTC14) is a protein-coding gene in humans, encoding a protein characterized by the presence of tetratricopeptide repeat (TPR) domains[1][3][5][9][12]. TTC14 is predicted to participate in nucleic acid binding and may be involved in diverse protein-protein interactions due to its TPR motifs[3][5][6]. The protein displays a high degree of intrinsic disorder, particularly in its C-terminal region, which is suggested to facilitate multiple molecular interactions[2]. TTC14 is ubiquitously expressed and has multiple alternatively spliced forms[2]. TTC14 is not considered a classical therapeutic target (such as a receptor, enzyme, or transporter), and its specific physiological and pathological roles remain poorly characterized[1][3][5][13]; however, genetic associations link it to primary ciliary dyskinesia, implicating a potential, though incompletely defined, role in human disease[3]. No clinically relevant drugs or validated biomarkers are currently reported for TTC14.

Other names

Tetratricopeptide repeat protein 14KIAA1980UNQ5813/PRO19630TPR repeat protein 14FLJ00166DRDL5813PRO19630TTC14