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Tetratricopeptide repeat domain 31 (TTC31)
- Target
- TTC31
- Molecular classification
- Other (TPR-domain containing protein)
01
Overview
Tetratricopeptide repeat domain 31 (TTC31) is a protein characterized by the presence of tandem tetratricopeptide repeat (TPR) motifs, which are known to mediate protein-protein interactions[5]. While the precise biological function of TTC31 remains incompletely defined, experimental evidence suggests that it participates in the regulation of centrosome duplication and maintenance of chromosome stability during cell division[2]. Knockdown of TTC31 in cell models leads to centrosome overduplication and chromosome congression defects, linking it to cell cycle regulation and genomic integrity[2]. TTC31 is a member of the broader family of TPR-containing proteins, which are implicated in processes such as cell cycle regulation, transcriptional control, and protein transport[5]. Despite this, TTC31 is not currently considered a validated therapeutic target, and no drugs or biomarkers are specifically associated with its modulation[1][2][5][7].
- Other names
- TPR repeat protein 31Tetratricopeptide repeat protein 31FLJ12788
02
Biological functions
Cell cycle regulationCentrosome duplicationChromosome stabilityProtein-protein interactionsCellular homeostasis
03
Disease associations
Other (no direct disease association established; limited evidence for a role in chromosome instability and potential involvement in cancer contexts; GeneCards lists Adams-Oliver Syndrome as a possible association)
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