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Tetratricopeptide repeat domain 36 (TTC36)

Target: TTC36
Molecular classification: Other (TPR domain-containing protein), Chaperone-associated protein

Overview

Tetratricopeptide repeat domain 36 (TTC36) is a human protein-coding gene that encodes a protein containing three tetratricopeptide repeats. These motifs mediate protein-protein interactions typical of TPR family members, and TTC36 acts as a chaperone for heat shock protein 70. Emerging evidence suggests a tumor suppressor role, particularly in hepatocellular carcinoma, as its expression is often downregulated in that context and it promotes apoptosis. TTC36 is also associated with certain metabolic disorders such as tyrosinemia type III[3].

Other names: TTC36Tetratricopeptide repeat protein 36

Biological functions

Chaperone activity for heat shock protein 70May function as a tumor suppressor (promoting apoptosis)

Disease associations

Cancer (potential tumor suppressor role in hepatocellular carcinoma)Tyrosinemia, type III (reported association)

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