Tetratricopeptide repeat domain 5 (TTC5)

Tetratricopeptide repeat domain 5 (TTC5) is a conserved protein containing multiple tetratricopeptide repeat (TPR) motifs, which are structural domains mediating protein–protein interactions and the assembly of multiprotein complexes[2][5]. TTC5 acts as a transcriptional cofactor and adaptor protein, regulating key cellular processes such as the DNA damage response, TP53/p53 stabilization and activation, heat-shock response, chromatin modification, autophagy, actin dynamics, and mRNA catabolism[3][4][5]. In stress conditions, TTC5 forms complexes with the histone acetyltransferase p300 (EP300) and coactivators like JMY to facilitate the activation of p53-dependent gene expression, promoting cell cycle arrest or apoptosis after DNA damage[3][4][5]. TTC5 is also required for survival and self-renewal of acute myeloid leukemia (AML) cells, acting partly through positive regulation of anti-apoptotic BCL2 expression and suppression of pro-apoptotic gene expression, in cooperation with p300/EP300[3]. TTC5 is broadly expressed, including in hematopoietic tissues; its dysfunction is associated with neurodevelopmental disorders and intellectual disability[4]. No approved drugs directly target TTC5, but its critical roles in apoptosis and cancer reveal potential therapeutic interest, particularly in hematological malignancies[3].

Other names

Tetratricopeptide repeat protein 5TPR repeat protein 5Protein StrapStrapStress-responsive activator of p300