Tetratricopeptide repeat domain protein 39B (TTC39B)

Tetratricopeptide repeat domain protein 39B (TTC39B) is a scaffolding protein characterized by containing TPR motifs that facilitate protein–protein interactions[1][3]. It regulates lipid metabolism, particularly by promoting the ubiquitination and proteasomal degradation of liver X receptor (LXR) proteins, which are nuclear receptors critical for cholesterol and HDL homeostasis[2][1]. Genetic variants and loss of function in TTC39B lead to increased HDL cholesterol, alterations in LXR signaling, protection against diet-induced hepatic steatosis, and reduced atherosclerosis in animal models[1]. TTC39B's expression is implicated in pigment biology, influencing carotenoid coloration via lipid–carotenoid metabolic pathways in non-mammalian animals[3]. TTC39B is not a classical receptor or enzyme but represents a regulatory scaffold in lipid and possibly pigment metabolism; while not yet the target of therapeutics, it is considered a novel and promising molecular target for cardiovascular and metabolic diseases[1][2].

Other names

Tetratricopeptide repeat protein 39BC9orf52TPR repeat protein 39BFLJ33868

Drug-mediated inhibition or modulation could alter LXR stability, HDL levels, and downstream lipid metabolism[1][2]